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DETAILS

This gentle leave on granactive retinoid serum helps promote a smooth, radiant-looking complexion while supporting skin clarity and hydration.

Our Pro+ Bio Resurfacing Retinol RX serum is the first in our range to combine postbiotic technology with a next-generation retinoid. This gentle formula is designed for those introducing a retinoid into their routine while maintaining skin comfort. The inclusion of Granactive Retinoid is balanced with soothing ingredients that help reduce the appearance of redness and support a visibly calm, even-toned complexion.

If you're easing into a retinoid routine, start with our Pro+ Bio Resurfacing Retinol ALT - a plant-based alternative featuring Bakuchiol to refine and visibly brighten the skin.

This product is not pregnancy or breastfeeding safe.

Take 1-2 pumps of this serum and gently pat onto clean skin. Apply in the evening. Limit initial use, gradually increasing when tolerated.

Retinols can increase skin’s sensitivity to the sun. Always wear sunscreen and appropriate sun protection while using this product.

Not pregnancy or breastfeeding safe.

✔ Verified Plastic Recovery
✔ No Nasties
✔ Biome Friendly
✔ Made In Australia
✔ Vegan Friendly
✔ Cruelty Free

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Next-Generation Retinoid for a Smooth, Radiant-Looking Complexion

The AMPERNA® Pro+ Bio Resurfacing Retinol RX is an advanced leave-on serum featuring Granactive Retinoid combined with soothing ingredients such as azelaic acid salt, niacinamide, liquorice root extract, and zinc & copper gluconates. Designed to promote a radiant, even-toned appearance, it helps support skin clarity and hydration while maintaining comfort. With AMPERNA®’s unique postbiotic complex, this formula brings next-generation retinoid technology together with microbiome-conscious care.

INGREDIENTS EXPLAINED

  • 5 stars: 20 (100%)
  • 4 stars: 0 (0%)
  • 3 stars: 0 (0%)
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Anonymous (Sydney, AU)
Retinol for sensitive skin

I have really sensitive skin and this is the first retinol I have ever used. I did not have any flare ups after using it and after a few weeks my skin felt smoother and looked brighter.

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Steph D. (Melbourne, AU)
The only retinol I can use!

I love this retinol so so much. It helps keep my perioral dermatitis flare ups at bay, and is the only retinol I've used that hasn't hurt my skin!

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Jen (Haslemere, GB)
Brilliant gentle retinol!

So my skin generally hates EVERYTHING. the soothing duo is quite literally the only skincare product I've ever used that hasn't upset my skin in some way. I've been using it since January 2023 and have bought it over and over. I'm 32 and everyone tells me how good my skin is (since using Amperna!). But I felt I wanted a bit of an extra boost to deal with some texture I have. I was nervous to try the retinol but I've had absolutely no issues. I use it once or twice a week, and I find that it makes my skin a little dry but that's to be expected, and this resolves very quickly, within a few days. It's really refined my skin's texture, just make sure to use sunscreen every day when using retinol and put it on your skin when your skin is completely dry! I noticed once it made me itchy and this is because my face was damp when I applied. After doing some research this is apparently a big retinol no-no! Great product, as always. Thank you Amperna.

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Lisa

I love Amperna its great on my skin but it’s expensive

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Holly J. (Perth, AU)
Gentle

I have rosacea prone skin but this retinol is so gentle I can use it without any redness or irritation. My skin feels so soft the following morning. Love it!

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Zoe D. (Christchurch, NZ)
The only retinol I'll use

I've never been able to use a retinol consistently because they always aggravate my skin. Took a gamble on this one and glad I did! I worked up to using it daily/every second day but unlike most other retinols, I didn't even get much initial redness or peeling. Definitely less itchiness and discomfort than other retinols and I notice my skin is smoother and looks brighter after a few weeks of regular use.

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Peter H. (Wellington, NZ)
Skin enhancing

I have sensitive, dry skin so was a little anxious to try a retinol product but I’m so pleased I did. It’s been 2 months since I started using Superfoliate and I introduced it very slowly, starting with twice a week but now tolerating every 2nd night. This product has addresses both dryness and oiliness and my skin feels so comfortable and soft. It is also clearer and I don’t get many breakouts these days. I did have to push through some days of skin pinkness and dry patches but the result was worth it! Would highly recommend!

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Steph D. (Melbourne, AU)
Amazing!

My derm prescribed me with retinol for continuous use, but it was too harsh for my skin. Decided to try this, and I'm so glad I did! I haven't had any irritation, and my skin looks great

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Jessica O. (Sydney, AU)
Gentle Retinol

Once the soothing duo got my PD flare up under control, I wanted to do something about my skin's hyperpigmentation and texture. I was apprehensive but this has been the gentlest yet effective retinol I have used. It has become a regular part of my routine.

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Helen L. (Sydney, AU)
Glowing skin

I’ve been using the soothing serum for about a year (can’t go without it now!) and slowly started introducing this retinol in my skincare. This literally makes your skin glow the next day - even more than la mer! If you have sensitive skin, I find you do have to start gentle with this (once every 2-3 nights) before building up the frequency. Can’t wait to see the long term change this will have on my skin.

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D.M. (Sydney, AU)
Loving this retinol

Other retinols have really bothered my skin- this one is wonderfully gentle but still really effective. Its another Amperna win for me!

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Amelia
Skin so smooth

I had PD for year and this is the only range that actually calmed it down. I haven’t had a flair since I starting using these products. I recently introduced the Superfoliant to my regime and my skin feels so smooth in the morning. I can definitely feel the difference. It’s the best range out there for anyone with PD.

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Sarah S.
Love these products

I have sensitive skin and have been struggling with Perioral Dermatitis. I ordered the Hydrate (lightweight soothing emulsion) and the Rescue (soothing serum). These products have really made a difference in my skin. My dermatitis has calmed down and my skin feels more healthy and hydrated. Thank you!!!

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Amelia
Heaven sent

This product is the best retinol I have ever used, I have extremely sensitive skin and I was able to build this up in my routine very quickly! The next morning when I wake up my skin is so refreshed, less breakouts, less redness and no irritation. Amperna products have honestly changed my life and I couldn’t be happier than I am with a brand as a whole.

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Kahlia
Love it!

I was nervous adding this into my Amperna regime, worried it would be too strong for my super sensitive skin. I shouldn’t have been concerned! This is the 5th product from Amperna that I’ve used and I never have issues. It’s incredible and unbelievable all at the same time. So happy! Definitely noticed smoother skin and a more lively and dewy complexion. My only downer is that I don’t love the smell but that’s totally ok. Definitely worth adding to your regime if you haven’t already.

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Tammy B.
Amazed

I have been using Amperna for almost 3 years and can’t say enough about it. Like a lot of people I found it after my diagnosis of Perioral Dermatitis, I love what Amperna has done for my skin and my confidence. I finally tried the Retinol and am so happy I did, I love it! I now use the whole line and will never look back! 💛

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M
Amazing stuff!

This is my first retinol use as I have had PD and was too scared to try one before but wanted to try after the soothing duo helped my skin so much! I have been using since April and have seen a real change around some softening of wrinkles and my skin is feeling so soft. Only been using Amperna products on my skin and such an improvement. Really happy with results so far!

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Shawna B.
Amperna rocks!!!!

So, I’ve left testimonials and tell everyone I know about your products but I just wanted to tell you directly how life changing your sunscreen has been for me. I beg you to never ever change the formula!!!!

I’m 45 years old and have spent thousands of dollars trying to find a sunscreen that didn’t cause breakouts. I’m one of those people that just looks at a product and a blemish appears! Yours is the ONLY sunscreen that has ever worked without the embarrassment of causing acne. And it’s safe?!?! I’m in love!

I live in one of the sunniest places on the planet, Phoenix, Arizona, USA, and was skipping sunscreen because I’d rather deal with sun damage than yet another blemish and acne scar from another supposed “noncomedogenic” product. Sad, dangerous and true.

Your products might have saved my life...at minimum my looks and sanity! I’m virtually blemish free for the first time in my whole life.

Cleanser, emollient, sunscreen & retinol...it’s like a long nightmare has finally ended and I am victorious. I have found my products!

Thank you from the bottom of my heart. I hope you make a billion dollars and change the world in the process. Amperna rocks!!!!

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Elizabeth O.
Baby soft skin!!

I have sensitive skin so I’m always hesitant to try Retinols but I knew Amperna would be different...and it was! I have been using this serum alongside my other Amperna products for several weeks and noticed a huge difference. My skin is soooo soft and my pores have minimized. I love this retinol!

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Carol V.
best retinol i've ever used!

This was recommended to me by Kiri and this was beyond wonderful. I've tried a few retinols on the market and they've either been too harsh or don't do anything significant. I've only used this 4 times in the past two weeks, and it's already made a difference in my hyperpigmentation. I cannot recommend this enough :)

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Kiri's Story

Before creating AMPERNA®, I lived with reactive skin. It was frustrating and often isolating, as I struggled to find products that didn’t make things worse.

That experience inspired me to develop a range that is gentle, simple, and supportive for skin, so others searching for calmer, more comfortable routines would have options they could turn to.

AMPERNA® is the result of that journey. Every product is guided by the same philosophy: kind formulations, inspired by real skin stories.

Frequently Asked Questions

  • Start 2–3 times per week and gradually increase frequency as your skin adjusts. Always listen to your skin and reduce frequency if irritation occurs.

  • No. This product is not pregnancy or breastfeeding safe.

  • Yes. Retinoids can make skin more sensitive to the sun, so it’s important to apply sunscreen during the day while using this product.

  • Yes. This formula is balanced with soothing ingredients and has been tested on delicate and easily unsettled skin. We recommend introducing it slowly and layering with hydration.

  • All AMPERNA® products are made in Australia in a certified manufacturing facility. They are tested regularly throughout the manufacturing process and meet Australia’s strict quality control standards.