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DETAILS

This gentle leave on granactive retinoid serum helps promote a smooth, radiant-looking complexion while supporting skin clarity and hydration.

Our Pro+ Bio Resurfacing Retinol RX serum is the first in our range to combine postbiotic technology with a next-generation retinoid. This gentle formula is designed for those introducing a retinoid into their routine while maintaining skin comfort. The inclusion of Granactive Retinoid is balanced with soothing ingredients that help reduce the appearance of redness and support a visibly calm, even-toned complexion.

If you're easing into a retinoid routine, start with our Pro+ Bio Resurfacing Retinol ALT - a plant-based alternative featuring Bakuchiol to refine and visibly brighten the skin.

This product is not pregnancy or breastfeeding safe.

Take 1-2 pumps of this serum and gently pat onto clean skin. Apply in the evening. Limit initial use, gradually increasing when tolerated.

Retinols can increase skin’s sensitivity to the sun. Always wear sunscreen and appropriate sun protection while using this product.

Not pregnancy or breastfeeding safe.

✔ Certified Plastic Negative
✔ No Nasties
✔ Biome Friendly
✔ Made In Australia
✔ Vegan Friendly
✔ Cruelty Free

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Next-Generation Retinoid for a Smooth, Radiant-Looking Complexion

The AMPERNA® Pro+ Bio Resurfacing Retinol RX is an advanced leave-on serum featuring Granactive Retinoid combined with soothing ingredients such as azelaic acid salt, niacinamide, liquorice root extract, and zinc & copper gluconates. Designed to promote a radiant, even-toned appearance, it helps support skin clarity and hydration while maintaining comfort. With AMPERNA®’s unique postbiotic complex, this formula brings next-generation retinoid technology together with microbiome-conscious care.

INGREDIENTS EXPLAINED

Customer Reviews

Based on 18 reviews
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Jen (Haslemere, GB)
Brilliant gentle retinol!

So my skin generally hates EVERYTHING. the soothing duo is quite literally the only skincare product I've ever used that hasn't upset my skin in some way. I've been using it since January 2023 and have bought it over and over. I'm 32 and everyone tells me how good my skin is (since using Amperna!). But I felt I wanted a bit of an extra boost to deal with some texture I have. I was nervous to try the retinol but I've had absolutely no issues. I use it once or twice a week, and I find that it makes my skin a little dry but that's to be expected, and this resolves very quickly, within a few days. It's really refined my skin's texture, just make sure to use sunscreen every day when using retinol and put it on your skin when your skin is completely dry! I noticed once it made me itchy and this is because my face was damp when I applied. After doing some research this is apparently a big retinol no-no! Great product, as always. Thank you Amperna.

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Lisa

I love Amperna its great on my skin but it’s expensive

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Holly James (Perth, AU)
Gentle

I have rosacea prone skin but this retinol is so gentle I can use it without any redness or irritation. My skin feels so soft the following morning. Love it!

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Zoe Deans (Christchurch, NZ)
The only retinol I'll use

I've never been able to use a retinol consistently because they always aggravate my skin. Took a gamble on this one and glad I did! I worked up to using it daily/every second day but unlike most other retinols, I didn't even get much initial redness or peeling. Definitely less itchiness and discomfort than other retinols and I notice my skin is smoother and looks brighter after a few weeks of regular use.

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Peter Harache (Wellington, NZ)
Skin enhancing

I have sensitive, dry skin so was a little anxious to try a retinol product but I’m so pleased I did. It’s been 2 months since I started using Superfoliate and I introduced it very slowly, starting with twice a week but now tolerating every 2nd night. This product has addresses both dryness and oiliness and my skin feels so comfortable and soft. It is also clearer and I don’t get many breakouts these days. I did have to push through some days of skin pinkness and dry patches but the result was worth it! Would highly recommend!

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Kiri's Story

Before creating AMPERNA®, I lived with reactive skin. It was frustrating and often isolating, as I struggled to find products that didn’t make things worse.

That experience inspired me to develop a range that is gentle, simple, and supportive for skin, so others searching for calmer, more comfortable routines would have options they could turn to.

AMPERNA® is the result of that journey. Every product is guided by the same philosophy: kind formulations, inspired by real skin stories.

Frequently Asked Questions

  • Start 2–3 times per week and gradually increase frequency as your skin adjusts. Always listen to your skin and reduce frequency if irritation occurs.


  • No. This product is not pregnancy or breastfeeding safe.


  • Yes. Retinoids can make skin more sensitive to the sun, so it’s important to apply sunscreen during the day while using this product.


  • Yes. This formula is balanced with soothing ingredients and has been tested on delicate and easily unsettled skin. We recommend introducing it slowly and layering with hydration.

  • All AMPERNA® products are made in Australia in a certified manufacturing facility. They are tested regularly throughout the manufacturing process and meet Australia’s strict quality control standards.